diff --git a/debezium-connector-oracle/src/main/java/io/debezium/connector/oracle/OracleConnection.java b/debezium-connector-oracle/src/main/java/io/debezium/connector/oracle/OracleConnection.java
index 10855e38d..abd898b51 100644
--- a/debezium-connector-oracle/src/main/java/io/debezium/connector/oracle/OracleConnection.java
+++ b/debezium-connector-oracle/src/main/java/io/debezium/connector/oracle/OracleConnection.java
@@ -55,6 +55,11 @@ public class OracleConnection extends JdbcConnection {
      */
     private static final Pattern ADT_INDEX_NAMES_PATTERN = Pattern.compile("^\".*\"\\.\".*\".*");
 
+    /**
+     * Pattern to identify a hidden column based on redefining a table with the {@code ROWID} option.
+     */
+    private static final Pattern MROW_PATTERN = Pattern.compile("^M_ROW\\$\\$");
+
     /**
      * A field for the raw jdbc url. This field has no default value.
      */
@@ -228,7 +233,9 @@ public List<String> readTableUniqueIndices(DatabaseMetaData metadata, TableId id
     @Override
     protected boolean isTableUniqueIndexIncluded(String indexName, String columnName) {
         if (columnName != null) {
-            return !SYS_NC_PATTERN.matcher(columnName).matches() && !ADT_INDEX_NAMES_PATTERN.matcher(columnName).matches();
+            return !SYS_NC_PATTERN.matcher(columnName).matches()
+                    && !ADT_INDEX_NAMES_PATTERN.matcher(columnName).matches()
+                    && !MROW_PATTERN.matcher(columnName).matches();
         }
         return false;
     }
diff --git a/debezium-connector-oracle/src/test/java/io/debezium/connector/oracle/OracleConnectorIT.java b/debezium-connector-oracle/src/test/java/io/debezium/connector/oracle/OracleConnectorIT.java
index 44da393c3..a9c304d7e 100644
--- a/debezium-connector-oracle/src/test/java/io/debezium/connector/oracle/OracleConnectorIT.java
+++ b/debezium-connector-oracle/src/test/java/io/debezium/connector/oracle/OracleConnectorIT.java
@@ -4176,6 +4176,30 @@ public void shouldNotDiscardTransactionWhenNoEventThresholdSet() throws Exceptio
         }
     }
 
+    @Test
+    @FixFor("DBZ-5356")
+    public void shouldUniqueIndexWhenAtLeastOneColumnIsExcluded() throws Exception {
+        TestHelper.dropTable(connection, "dbz5356");
+        try {
+            connection.execute("CREATE TABLE dbz5356 (id numeric(9,0), data varchar2(50))");
+            connection.execute("CREATE UNIQUE INDEX dbz5356_idx ON dbz5356 (upper(data), id)");
+            TestHelper.streamTable(connection, "dbz5356");
+
+            Configuration config = TestHelper.defaultConfig()
+                    .with(OracleConnectorConfig.TABLE_INCLUDE_LIST, "DEBEZIUM\\.DBZ5356")
+                    .build();
+
+            start(OracleConnector.class, config);
+            assertConnectorIsRunning();
+
+            waitForStreamingRunning(TestHelper.CONNECTOR_NAME, TestHelper.SERVER_NAME);
+            stopConnector();
+        }
+        finally {
+            TestHelper.dropTable(connection, "dbz5356");
+        }
+    }
+
     private void testTableWithForwardSlashes(String tableName, String topicTableName) throws Exception {
         final String quotedTableName = "\"" + tableName + "\"";
         TestHelper.dropTable(connection, quotedTableName);
diff --git a/debezium-core/src/main/java/io/debezium/jdbc/JdbcConnection.java b/debezium-core/src/main/java/io/debezium/jdbc/JdbcConnection.java
index 189407c0e..97e813933 100644
--- a/debezium-core/src/main/java/io/debezium/jdbc/JdbcConnection.java
+++ b/debezium-core/src/main/java/io/debezium/jdbc/JdbcConnection.java
@@ -1326,6 +1326,7 @@ public List<String> readPrimaryKeyNames(DatabaseMetaData metadata, TableId id) t
 
     public List<String> readTableUniqueIndices(DatabaseMetaData metadata, TableId id) throws SQLException {
         final List<String> uniqueIndexColumnNames = new ArrayList<>();
+        final List<String> excludedIndexNames = new ArrayList<>();
         try (ResultSet rs = metadata.getIndexInfo(id.catalog(), id.schema(), id.table(), true, true)) {
             String firstIndexName = null;
             while (rs.next()) {
@@ -1335,10 +1336,20 @@ public List<String> readTableUniqueIndices(DatabaseMetaData metadata, TableId id
                 if (firstIndexName == null) {
                     firstIndexName = indexName;
                 }
-                if (!isTableUniqueIndexIncluded(indexName, columnName)) {
-                    continue;
+                if (indexName != null) {
+                    boolean indexIncluded = isTableUniqueIndexIncluded(indexName, columnName);
+                    if (!indexIncluded && !excludedIndexNames.contains(indexName)) {
+                        excludedIndexNames.add(indexName);
+                    }
+                    if (excludedIndexNames.contains(indexName)) {
+                        // index has been excluded, skip further processing
+                        if (!uniqueIndexColumnNames.isEmpty()) {
+                            uniqueIndexColumnNames.clear();
+                        }
+                        continue;
+                    }
                 }
-                // Only first unique index is taken into consideration
+                // Only first non-excluded unique index is taken into consideration
                 if (indexName != null && !indexName.equals(firstIndexName)) {
                     return uniqueIndexColumnNames;
                 }